Sanctum Sanctorum -- Path of Exile

A Sanctum run contains 4 floors, each containing 8 rooms. The 8th room of each floor always contains a Boss. Players can choose to engage in a room every time they encounter the portal to the Sanctum in an area or map, or defer up to 8 rooms (1 floor) to be run consecutively at a later time. Crashing during a Sanctum room will reset progress for that room and will resume the same area on your next map. Aureus and rewards are only locked in upon successful completion of a room. Each Sanctum run is independent between characters on the same account.

Sanctum Sanctorum Sanctum Room

Name Icon Floor Contains
Sanctum Sanctorum Sanctum Necropolis

All room types other than boss rooms can become Afflicted. Afflicted rooms are indicated by a purple border and cause the character to gain an Affliction on entry.

Each room contains several Guard unique monsters, as well as one of three tasks to complete the room:

  • Find the Exit (locate the exit door)
  • Defeat all the Guards (defeat every unique Guard)
  • Survive (avoid the traps)
  • Defeat the Boss (minibosses based on map bosses)

Buy PoE Currency Cheap

  • PoE Currency (6% off coupon: z123). Path of Exile item and currency. Payment: PayPal, Skrill, Cryptocurrencies.

The Sanctum Sanctorum is a highly anticipated and mysterious room in The Forbidden Sanctum, shrouded in legend and whispered rumors. While its exact nature and location remain somewhat unknown, speculation runs wild among Exiles about what challenges and rewards await within its hallowed halls. Here's what we know so far:

Myths and Theories:

  • Lycia's Inner Sanctum: Many believe the Sanctum Sanctorum could be Lycia's innermost sanctum, a place where she hides her most treasured secrets and powerful artifacts.
  • Final Trial or Boss Encounter: Rumors suggest the Sanctum Sanctorum might be the final chamber of The Forbidden Sanctum, holding a formidable boss or the ultimate challenge before claiming victory.
  • Reward Chamber of Legends: Theories speculate it might be a hidden treasure room brimming with legendary relics, boons, and even unique Sanctum-specific items.

Possible Features:

  • Enhanced Difficulty: Based on its ominous name, the Sanctum Sanctorum is likely to present the most challenging encounter in the Sanctum, demanding masterful skill and strategic planning.
  • Puzzles and Traps: Rumors hint at intricate puzzles guarding the secrets within, alongside deadly traps and challenging environmental hazards.
  • Unique Mechanics: It's speculated that the Sanctum Sanctorum might introduce entirely new mechanics, gameplay elements, or boss fight mechanics unlike anything encountered before.

Challenges and Risks:

  • Reaching the Sanctum: Accessing the Sanctum Sanctorum might require fulfilling specific conditions or completing hidden objectives within the other Sanctum floors.
  • High Mortality Rate: The rumors surrounding its difficulty suggest a high chance of Exiles perishing within the Sanctum Sanctorum, making it a true test of skill and survival.
  • Unpredictable Rewards: While the potential rewards are enticing, their nature and acquisition remain unknown, adding an element of risk and surprise to the challenge.

Overall, the Sanctum Sanctorum remains a fascinating mystery in The Forbidden Sanctum, holding the potential for unparalleled rewards and the ultimate test of an Exile's prowess. As more information comes to light, keep your eyes peeled for clues and secrets within the Sanctum, and be prepared to face the ultimate challenge for a shot at claiming the legendary treasures said to lie within!

Remember, Exiles, the path to the Sanctum Sanctorum is shrouded in uncertainty. Prepare for the unexpected, hone your skills, and embrace the risk for a chance to become one of the few to conquer this legendary chamber!


List of Sanctum Rooms

Name Icon Floor Contains
Abandoned Library Sanctum Archives
Templar Annals Sanctum Archives
Chambers of Inscription Sanctum Archives
Holy Trials Sanctum Archives
Scriptorium Sanctum Archives
Candlelit Chapel Sanctum Archives
Merchant Sanctum Archives Contains Merchant
Accursed Pact Sanctum Archives Contains Accursed Pact
Fountain Sanctum Archives Contains Fountain
Afflicted Fountain Sanctum Archives Contains Afflicted Fountain
Benevolent Fountain Sanctum Archives Contains Benevolent Fountain
Radiant Fountain Sanctum Archives Contains Radiant Fountain
Offer Sanctum Archives Offers Items on Completion
Major Treasure Sanctum Archives Contains Major Treasure Reward
Minor Treasure Sanctum Archives Contains Minor Treasure Reward
Candlelit Chapel Sanctum Archives Contains Varakath, the Waxen
Battleground Sanctum Vaults
Decrepit Cellar Sanctum Vaults
Derelict Caverns Sanctum Vaults
Gauntlet Sanctum Vaults
Reliquary Sanctum Vaults
Experimentation Chamber Sanctum Vaults
Merchant Sanctum Vaults Contains Merchant
Accursed Pact Sanctum Vaults Contains Accursed Pact
Fountain Sanctum Vaults Contains Fountain
Afflicted Fountain Sanctum Vaults Contains Afflicted Fountain
Benevolent Fountain Sanctum Vaults Contains Benevolent Fountain
Radiant Fountain Sanctum Vaults Contains Radiant Fountain
Offer Sanctum Vaults Offers Items on Completion
Major Treasure Sanctum Vaults Contains Major Treasure Reward
Minor Treasure Sanctum Vaults Contains Minor Treasure Reward
Candlelit Chapel Sanctum Vaults Contains Braom and Uzar, the Experiments
Halls of Worship Sanctum Cathedral
Unholy Lair Sanctum Cathedral
Infernum Sanctum Cathedral
Crucible Sanctum Cathedral
Sanctum Bellum Sanctum Cathedral
Hall of Mirrors Sanctum Cathedral
Merchant Sanctum Cathedral Contains Merchant
Accursed Pact Sanctum Cathedral Contains Accursed Pact
Offer Sanctum Cathedral Offers Items on Completion
Fountain Sanctum Cathedral Contains Fountain
Afflicted Fountain Sanctum Cathedral Contains Afflicted Fountain
Benevolent Fountain Sanctum Cathedral Contains Benevolent Fountain
Radiant Fountain Sanctum Cathedral Contains Radiant Fountain
Major Treasure Sanctum Cathedral Contains Major Treasure Reward
Minor Treasure Sanctum Cathedral Contains Minor Treasure Reward
Candlelit Chapel Sanctum Cathedral Contains Xenathar, Templar Reaper
Lost Catacombs Sanctum Necropolis
Desecrated Crypts Sanctum Necropolis
Undercroft Sanctum Necropolis
Entombment Sanctum Necropolis
Mausoleum Sanctum Necropolis
Sanctum Sanctorum Sanctum Necropolis
Fountain Sanctum Necropolis Contains Fountain
Afflicted Fountain Sanctum Necropolis Contains Afflicted Fountain
Benevolent Fountain Sanctum Necropolis Contains Benevolent Fountain
Radiant Fountain Sanctum Necropolis Contains Radiant Fountain
Merchant Sanctum Necropolis Contains Merchant
Accursed Pact Sanctum Necropolis Contains Accursed Pact
Offer Sanctum Necropolis Offers Items on Completion
Major Treasure Sanctum Necropolis Contains Major Treasure Reward
Minor Treasure Sanctum Necropolis Contains Minor Treasure Reward
Candlelit Chapel Sanctum Necropolis Contains Lycia, Unholy Heretic