The first 15 Waves have been removed from the Simulacrum. Usually, characters reaching this content were a high enough level that the first waves were tedious and unrewarding.
We've also added more opportunities to obtain specific Unique Items, such as Voices, by defeating the Bosses as you complete Waves.
The Quantity and Rarity bonus applied to monsters from Delirium encounters has been lowered as is now more consistent across Monster rarities. Previously, Monsters of Normal rarity had a disproportionately larger amount of Quantity and Rarity being applied to them compared to Monsters of higher rarities.
Added a new Sextant modifiers which will cause maps in the associated Atlas region to contain Delirium encounters.
Reduced the chance for Map Areas to contain a Delirium Mirror by approximately 20%. The chance to encounter a Zana mission containing a Delirium encounter has also been lowered by the same amount.
Delirium Orbs are now exclusive to Delirium encounters
Added a new Cluster Jewel notable – Blood Artist: Grants a +14% to Physical Damage over time Multiplier if you’ve Spent Life Recently, and +20 to Strength.
Added a new Cluster Jewel notable – Phlebotomist: Grants a +14% to Physical Damage over Time Multiplier if you’ve dealt a Critical Strike Recently, and 20% increased Critical Strike Chance.
The Cluster Jewel notable Aerodynamics now grants 10% increased Projectile Speed (previously 20%).
The Cluster Jewel notable Brand Loyalty now causes Enemies to take 4% increased Damage for each of your Brands Attached to them (previously 5%).
The Cluster Jewel notable Dark Discourse now grants 6% increased Effect of your Curses (from 10%).
The Cluster Jewel notable Exposure Therapy now grants a +8% to Damage over Time Multiplier (previously +10%).
The Cluster Jewel notable First Among Equals now grants 6% increased effect of Non-Curse Auras from your Skills (previously 8%).
The Cluster Jewel notable Grand Design now grants 10% increased Brand Attachment Range (from 20%).
The Cluster Jewel notable Haemorrhage now grants a +15% to Damage over Time Multiplier for Ailments from Critical Strikes (previously 18%) and 30% increased Critical Strike Chance (previously 40%).
The Cluster Jewel notable Magnifier no longer grants 10% increased Area Damage.
The Cluster Jewel notable Rend no longer grants a +12% to Damage over Time Multiplier for Bleeding. It now grants a +12% to Physical Damage over Time Multiplier.
The Cluster Jewel notable Renewal now causes Minions to have 5% chance to deal Double Damage while they are on Full Life (previously 6%).
The Cluster Jewel notable Replenishing Presence now grants 6% increased effect of Non-Curse Auras from your Skills (previously 8%).
The Cluster Jewel notable Snowstorm now causes you to Gain 8% of Lightning Damage as Extra Cold Damage against Chilled Enemies (previously 10%).
The Cluster Jewel notable Stalwart Commander now causes Determination, Discipline and Grace to have 15% increased Aura Effect (previously 20%).
The Cluster Jewel notable Streamlined now grants 20% increased Projectile Speed (previously 30%).
The Cluster Jewel notable Surprise Sabotage now grants a +8% to Critical Strike Multiplier with Traps and Mines (previously 10%) and Trap and Mine Damage now Penetrates 4% Elemental Resistances (previously 5%).
The Cluster Jewel notable Tempered Arrowheads now causes Bow Skills to have 10% increased Skill Effect Duration (previously 20%).
The Cluster Jewel notable Vast Power now grants 3% increased Area of Effect per Power Charge, up to a maximum of 50% (previously uncapped).
The Cluster Jewel notable Vengeful Commander now causes Anger, Hatred and Wrath to have 15% increased Aura Effect (previously 20%).
The Cluster Jewel notable Wicked Pall now grants 30% increased Chaos Damage (previously 35%) and 5% increased Skill Effect Duration (previously 10%).
The Cluster Jewel notable Widespread Destruction now grants 6% increased Area of Effect (previously 10%).
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Lex Ejoris Changes(Atlas Passives)
Pathological now has a 5% chance to apply layers of Delirium to Maps found in Areas (previously 10%).
Compulsive Hoarder now has a 10% chance to cause Delirium encounters in Areas to generate three additional Reward types (previously 15%).
Maddening Incubator.
Determination, 
Discipline and Grace to have 15% increased Aura Effect (previously 20%).
Hatred and Wrath to have 15% increased Aura Effect (previously 20%).